Separated from his wife, Emma (Academy Award and Golden Globe-winner Jennifer Connelly – “A Beautiful Mind,”“Requiem for a Dream”), amnesiac John Murdoch (Rufus Sewell -- TV’s “The Eleventh Hour,” “The Illusionist”) awakens alone in a strange hotel to learn he is wanted for a series of brutal murders, but he can’t remember if he committed them or not. Indeed, most of his memories have completely vanished, and he becomes the focus of interest for both “mad genius” Dr. Schreber (Emmy Award and Golden Globe-winner Kiefer Sutherland -- TV's “24,” “Phone Booth”) and sympathetic detective Frank Bumstead (Academy Award-winner William Hurt -- “The Incredible Hulk,”“Broadcast News”). Attempting to unravel the twisted riddle of his identity, Murdoch encounters a group of ominous beings known as the “Strangers,” shadow-like figures who have collective memory and posses the ability to stop time and alter physical reality through a process called “The Tuning.”