In the United States, cytomegalovirus (CMV) is the leading congenital viral infection, affecting approximately 1 in every 200 babies. Fortunately, in most cases, patients have no symptoms or disabilities. However, about 10% of the newborns who test positive are symptomatic. In these patients, congenital CMV can be associated with long-term neurodevelopment sequelae, such as sensorineural hearing loss, cerebral palsy, and intellectual disability. Listen to experts in this podcast series discuss what clinicians need to know about congenital CMV, including pathophysiology, evolution in pregnancy, newborn screening, a patient's experience, prevention strategies, and how to build a healthcare team.