Insulin resistance is a condition characterized by an impaired response of cells to insulin, which causes an initial increase in insulin levels. This hyperinsulinemia can further promote fat storage and inflammation, worsening insulin resistance and resulting in the establishment of a vicious circle which can contribute to the development of conditions like type 2 diabetes and obesity. Breaking this vicious circle is as important as it is difficult. Changes in lifestyle and pharmacotherapy, such asmetformin, have been shown effective to improve insulin resistance and prevent its deleterious condition.

This podcast is part of the continuing medical education program entitled “The 2025 Learning Journey in Diabetes: A Case-Based InteractiveEducational Experience”, targeting endocrinologists, diabetologists, nurses and obstetricians.